pentobarbital will minimize the extent or impact of saxagliptin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.
pentobarbital will lower the extent or influence of conivaptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will minimize the level or result of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. The efficacy of hormonal contraceptives could possibly be reduced.
Remark: Barbiturates may possibly boost adverse effects, which includes respiratory depression, made by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates improve metabolism and reduce blood concentrations of TCAs.
pentobarbital will decrease the level or result of bedaquiline by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Keep away from coadministration of bedaquiline with strong CYP3A4 inducers as a result of likely for lessened therapeutic effect
pentobarbital will minimize the level or influence of darunavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Monoamine oxidase inhibitors (MAOI) may possibly inhibit barbiturate metabolism and extend barbiturate effects; check closely
pentobarbital will lessen the level or influence of nelfinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will reduce the extent or effect of ritonavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Reserve concomitant prescribing of such drugs in people for whom other therapy selections are insufficient. Restrict dosages and click here durations towards the bare minimum demanded. Keep track of carefully for signs of respiratory melancholy and sedation.
Contraindicated (1)pentobarbital will decrease the extent or outcome of lorlatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Comment: Barbiturates may well boost adverse effects, such as respiratory despair, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates raise metabolism and decrease blood concentrations of TCAs.
pentobarbital will lower the extent or impact of propafenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.
Observe Closely (2)pentobarbital will decrease the level or impact of oliceridine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. If coadministration with a CYP3A4 inducer is important, take into consideration increasing oliceridine dose till stable drug effects are attained; observe for indications of opioid withdrawal.